Author: Yu, V.S.
Paper Title Page
MOPORI09 Linear Accelerator for Demonstration of X-Ray Radiotherapy with Flash Effect 243
MOOPA01   use link to see paper's listing under its alternate paper code  
 
  • S.V. Kutsaev, R.B. Agustsson, S. Boucher, K. Kaneta, A.Yu. Smirnov, V.S. Yu
    RadiaBeam, Santa Monica, California, USA
  • A.R. Li, K. Sheng
    UCLA, Los Angeles, California, USA
  
  Funding: This project is funded by NIH, award number NIH R01CA255432.
Emerg­ing ev­i­dence in­di­cates that the ther­a­peu­tic win­dow of ra­dio­ther­apy can be sig­nif­i­cantly in­creased using ul­tra-high dose rate dose de­liv­ery (FLASH), by which the nor­mal tis­sue in­jury is re­duced with­out com­pro­mis­ing tumor cell killing. The dose rate re­quired for FLASH is 40 Gy/s or higher, 2-3 or­ders of mag­ni­tude greater than con­ven­tional ra­dio­ther­apy. Among the major tech­ni­cal chal­lenges in achiev­ing the FLASH dose rate with X-rays is a lin­ear ac­cel­er­a­tor that is ca­pa­ble of pro­duc­ing such a high dose rate. We will dis­cuss the de­sign of a high dose rate 18 MeV linac ca­pa­ble of de­liv­er­ing 100 Gy/s of col­li­mated X-rays at 20 cm. This linac is being de­vel­oped by a Ra­di­a­Beam/UCLA col­lab­o­ra­tion for a pre­clin­i­cal sys­tem as a demon­stra­tion of the FLASH ef­fect in small an­i­mals. 		 
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DOI • reference for this paper ※ https://doi.org/10.18429/JACoW-LINAC2022-MOPORI09  
About • Received ※ 19 August 2022 — Revised ※ 22 August 2022 — Accepted ※ 29 August 2022 — Issue date ※ 02 September 2022
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