Author: Sheng, K.
Paper Title Page
MOPORI09 Linear Accelerator for Demonstration of X-Ray Radiotherapy with Flash Effect 243
MOOPA01   use link to see paper's listing under its alternate paper code  
  • S.V. Kutsaev, R.B. Agustsson, S. Boucher, K. Kaneta, A.Yu. Smirnov, V.S. Yu
    RadiaBeam, Santa Monica, California, USA
  • A.R. Li, K. Sheng
    UCLA, Los Angeles, California, USA
  Funding: This project is funded by NIH, award number NIH R01CA255432.
Emerging evidence indicates that the therapeutic window of radiotherapy can be significantly increased using ultra-high dose rate dose delivery (FLASH), by which the normal tissue injury is reduced without compromising tumor cell killing. The dose rate required for FLASH is 40 Gy/s or higher, 2-3 orders of magnitude greater than conventional radiotherapy. Among the major technical challenges in achieving the FLASH dose rate with X-rays is a linear accelerator that is capable of producing such a high dose rate. We will discuss the design of a high dose rate 18 MeV linac capable of delivering 100 Gy/s of collimated X-rays at 20 cm. This linac is being developed by a RadiaBeam/UCLA collaboration for a preclinical system as a demonstration of the FLASH effect in small animals.
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About • Received ※ 19 August 2022 — Revised ※ 22 August 2022 — Accepted ※ 29 August 2022 — Issue date ※ 02 September 2022
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