JACoW is a publisher in Geneva, Switzerland that publishes the proceedings of accelerator conferences held around the world by an international collaboration of editors.
TY - CONF AU - Kutsaev, S.V. AU - Agustsson, R.B. AU - Boucher, S. AU - Kaneta, K. AU - Li, A.R. AU - Sheng, K. AU - Smirnov, A.Yu. AU - Yu, V.S. ED - McIntosh, Peter ED - Burt, Graeme ED - Apsimon, Robert ED - Schaa, Volker R.W. TI - Linear Accelerator for Demonstration of X-Ray Radiotherapy with Flash Effect J2 - Proc. of LINAC2022, Liverpool, UK, 28 August-02 September 2022 CY - Liverpool, UK T2 - International Linear Accelerator Conference T3 - 31 LA - english AB - Emerging evidence indicates that the therapeutic window of radiotherapy can be significantly increased using ultra-high dose rate dose delivery (FLASH), by which the normal tissue injury is reduced without compromising tumor cell killing. The dose rate required for FLASH is 40 Gy/s or higher, 2-3 orders of magnitude greater than conventional radiotherapy. Among the major technical challenges in achieving the FLASH dose rate with X-rays is a linear accelerator that is capable of producing such a high dose rate. We will discuss the design of a high dose rate 18 MeV linac capable of delivering 100 Gy/s of collimated X-rays at 20 cm. This linac is being developed by a RadiaBeam/UCLA collaboration for a preclinical system as a demonstration of the FLASH effect in small animals. PB - JACoW Publishing CP - Geneva, Switzerland SP - 243 EP - 246 KW - linac KW - electron KW - solenoid KW - radiation KW - target DA - 2022/09 PY - 2022 SN - 2226-0366 SN - 978-3-95450-215-8 DO - doi:10.18429/JACoW-LINAC2022-MOPORI09 UR - https://jacow.org/linac2022/papers/mopori09.pdf ER -